The venom of the Brazilian wandering spider (Phoneutria nigriventer) can cause necrosis of the penis. That is, the death of the tissue of that organ. This can sometimes require amputation. But science found a way to use its chemical properties. Spider venom that works like Viagra could solve erectile dysfunction.
The large dose of venom distributed by the spider in nature causes very painful and long-lasting erections in mammals. These abnormally long erections are technically known as priapism. To the P. nigriventer It is also known as the banana spider. It is usually found in banana leaves. The body of this arachnid can reach five centimeters in length. It is one of the most poisonous spiders that exist.
synthetic molecule
But its venom could give clues to the next viagra. Scientists at the Federal University of Minas Gerais in Brazil made a synthetic version of the venom molecule. It’s called BZ371A and has already been tested with some success in mice and rats. By putting it in a gel and smearing it on the animals’ groins, erections were triggered.
This poison causes the release of nitric oxide in the body. In turn, it increases blood flow to the genitals. Viagra works in a similar way, by making the penis more sensitive to the release of nitric oxide. The treatment worked in old rats and in those with diseases such as hypertension and diabetes. It could be useful for human patients with these ailments.
Next step
Viagra and another anti-impotence drug, Cialis, don’t work for about 30% of men. There is a risk of lowering blood pressure if taken together with nitrates. There is a risk of complications for people with serious heart or liver problems. A pilot test carried out on men and women has shown that the gel is safe, although more will be done. Researchers hope it also works for female sexual dysfunction. Spider venom that works like Viagra may be the next step in these issues.
