What are organoids? They are small tissues and organs that are grown in the laboratory. They are anatomically correct and physiologically functional. Stem cell and tissue engineering make fiction a reality. That is why the miniature stem cell heart was created.
The attraction of organoids is obvious. They deliver tissues and mini-organs for medical and pharmaceutical research … without a donor. The Ecole Polytechnique de Lausanne has published an article about it. Be titual Recording of cardiogenesis in gastruloids. It’s in the journal Cell Stem Cell.
Dr. Matthias Lütolf is a leader in this field. They study the growth of organoids, 3D printing of organoids, and others. They revolutionize this discipline with their experiments. They produced an organoid that mimicked a mouse’s heart in its early embryonic stages.
The team is led by Giuliana Rossi. He grew his organoids from mouse embryonic stem cells under the right conditions. He said, “They are organized into structures that mimic aspects of architecture, cell composition, and tissue function in real organs.” Embryonic stem cells form a three-dimensional aggregate called a gastruloid. And it can follow the embryonic developmental stages of a mouse. Gastruloids are embryos made from stem cells.
They exposed mouse embryonic stem cells to a “cocktail” of three factors that are known to promote heart growth. After 168 hours, these resulting gastruloids showed signs of early cardiac development. For example, they expressed several genes that regulate cardiovascular development in the embryo. And they created something that resembles a network of vessels.
Most important is the development of a “front heart crescent domain”. This structure produced heart tissue with a beating ability similar to that of the embryonic heart.
This groundbreaking work opens a new dimension in the study of organoids. They can be used to mimic embryonic developmental stages. “Emerging heart cells are exposed to a similar context as the embryo.” The miniature heart stem cell will be the ideal platform to study organ development.
At this rate, they will soon have customized organs made from stem cells. Fiction once again overtaken by science.