Did it happen to you That sudden pain in the teeth from something very cold … almost unbearable. What is that for? What does science say What is the relationship between a cold and a toothache? A group of researchers examined it. They identified the cells and signals in cold-sensitive teeth. They recognize large drops in temperature and cause pain. People with cavities are more prone to these sensations: their teeth are more exposed.
The results were published in Advances in science. Provides information for new treatments such as toothpastes, plasters, or gums.
“As soon as you have a molecule to target, treatment is possible,” explained Katharina Zimmermann. She is the lead researcher on the study. This molecule is the cold-sensitive protein TRPC5.
Zimmermann works at the Friedrich-Alexander University in Erlangen-Nuremberg. He traced the position of this protein back to a particular type of tooth cell. It is the odontoblast between the soft inner pulp and the hard outer layer of the teeth. It consists of dentin and tooth enamel.
In contrast to the innermost layer, the dentin, the enamel has no sensations. This connects to the pulp, which contains nerve cells. You could be exposed to tooth decay or gum disease. And stimuli such as temperature or certain fluids cause pain.
The researchers looked at how toothache occurred in mice and humans. In normal mice, this icy contact triggered nervous activity. This indicated that the teeth felt the cold. This was not the case in mice (genetically modified) without TRPC5. Or in teeth that have been treated with a chemical that blocks TRPC5. “
TRPC5 transmits cold and causes nerves to fire and cause pain. She is responsible for the relationship between the common cold and toothache. This could be the body’s way of protecting the tooth from further damage.
Zimmermann says that “we found higher levels of TRPC5 in carious human teeth”. “We could develop a TRPC5 blocker for tape or rubber. It would be of great help in treating toothache or dentin hypersensitivity. ‘
A common home remedy, clove oil, contains a chemical called eugenol. This blocks TRPC5 channels. However, scientists do not recommend home treatments. Blocking the pain can provide temporary relief, although treating and preventing the cause is important.
“We cannot ignore the underlying causes of tooth sensitivity. Dentists can treat the cause by removing cavities. And recommend dentifrices for sensitive teeth.
In the future, TRPC5 blockers could be found in toothpastes and dental products to help prevent pain caused by sensitivity.